Anti-SFRP1分泌型卷曲相关蛋白 1 抗体
| 产品编号 | nrbe-12290A |
| 产品类型 | 小鼠单克隆抗体 |
| 英文名称 | Secreted Frizzled-Related Protein 1 |
| 中文名称 | 分泌型卷曲相关蛋白 1 |
| 英文别名 | |
| 产品应用 | ELISA=1：500-5000，WB=1：1000-5000，IF=1:100-500 Optimal working dilutions must be determined by the end user. Not yet tested in other applications. |
| 交叉反应 | Human，Mouse |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant Human SFRP1 protein |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M PBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze-thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SFRP1（Secreted Frizzled-Related Protein 1）是 Wnt 信号通路的关键拮抗剂，通过含半胱氨酸的结构域与 Wnt 配体或 Frizzled 受体结合，抑制通路激活，调控胚胎发育、细胞增殖及组织稳态。其表达异常与肿瘤（如结直肠癌、乳腺癌中常因启动子甲基化下调，促癌细胞增殖）、纤维化（如肝纤维化中表达异常影响细胞外基质沉积）等疾病密切相关。 |
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